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For eighteen months I have been administering salvarsan intravenously by the means of a 30 c.c. syringe. The manufacturers of this product have always advised that larger amounts of water be used (250 c.c. for 0.5 gm.). I have no hesitancy in giving 0.6 gm. in 30 c.c. of water. The results obtained have been so consistently successful that I think a description of the method employed not amiss.
In the directions for giving neosalvarsan it is advised that the drug (0.9 gm.) be given in 150 c.c. of water. In connection with my associates in the Bobbs and City Dispensary, I have given 3,000 injections of neosalvarsan (0.9 gm.) in 10 c.c. of water, using an ordinary glass syringe. The number of reactions was much less in this series of cases than when the gravity method was used and the solution was made up to 150 c.c., owing to
Brayton FA. A SIMPLIFIED METHOD OF ADMINISTERING SALVARSAN. JAMA. 1916;LXVI(25):1921–1922. doi:10.1001/jama.1916.25810510001010
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