Kaiserling and Orgler1 were the first investigators to call attention to the presence of anisotropic droplets or liquid crystals in the cortex of the human adrenal glands. Herrmann2 later studied a small number of human adrenals with regard to their content in the doubly refractive substance, and reports it uninfluenced by age, but diminished by wasting diseases. He observed its entire absence once in the adrenals of a 70-year-old woman dying from miliary tuberculosis, and again in the glands removed from a body with long-continued, chronic lung phthisis. The small number of glands studied was not sufficient, however, to permit drawing conclusions regarding the causal relationship between disease and the absence of the anisotropic droplets. White3 also merely reports the presence of doubly refractile droplets in the adrenals removed from thirty individuals dying from various diseases. Kawamura4 observed the anisotropic substance in a finely divided form
HIRSCH EF. A MORPHOLOGIC AND CHEMICAL STUDY OF THE DOUBLE REFRACTIVE FATS OF THE ADRENALS IN DELIRIUM TREMENS. JAMA. 1914;LXIII(25):2186–2190. doi:10.1001/jama.1914.02570250016005
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