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Article
July 1, 1916

PROTEOSE INTOXICATION: INTESTINAL OBSTRUCTION, PERITONITIS AND ACUTE PANCREATITIS

Author Affiliations

SAN FRANCISCO

From the George Williams Hooper Foundation for Medical Research, University of California Medical School.

JAMA. 1916;LXVII(1):15-17. doi:10.1001/jama.1916.02590010019004
Abstract

This communication deals with the etiology of the intoxication which develops in intestinal obstruction, general peritonitis and acute hemorrhagic pancreatitis. It has been demonstrated1 that the intoxication of intestinal obstruction is due to a primary proteose which may be precipitated by five volumes of 95 per cent. alcohol or by half saturation with ammonium sulphate. It is comparatively easy to isolate the poison from closed loops of the intestine. This proteose is very toxic and 100 mg. may suffice to poison fatally a 15 pound dog.

Peritonitis and pancreatitis have some clinical features in common with acute intestinal obstruction. At times there may be some difficulties in differential diagnosis. We propose to show that the intoxication in these three conditions is due in large part to toxic proteoses. There may well be other substances concerned, but I believe that the proteose is the most important factor in the toxic

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