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Article
December 19, 1914

AN INTERRELATION BETWEEN OXYGEN AND CARBON DIOXID IN THE BLOOD

JAMA. 1914;LXIII(25):2231-2232. doi:10.1001/jama.1914.02570250061022
Abstract

Among the numerous illustrations of physiologic regulation in the functions of the body none exhibits a greater degree of exactness than those furnished by the absorption and dissociation of the gases of the blood. With respect to the relation of oxygen to the circulating medium this has been demonstrated more strikingly perhaps than is true in the case of the carbon dioxid which ordinarily accompanies it. With the demonstration of the unique rôle of the latter gas in regulating respiration, and presumably other activities of the organism, has come an increasing knowledge of its exchange between tissues, blood and external atmosphere, respectively. The average arterial blood, in which the hemoglobin is 96 per cent. saturated, contains 17.76 c.c. of oxygen in combination per hundred c.c. of blood, or a total of 18.1 c.c. if to this is added the small amount of the gas which is in simple solution at

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