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December 26, 1914

ADRENAL PRECOCITYPRECOCIOUS DEVELOPMENT OF THE EXTERNAL GENITALS DUE TO HYPERNEPHROMA OF THE ADRENAL CORTEX

JAMA. 1914;LXIII(26):2286-2287. doi:10.1001/jama.1914.02570260022012

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Abstract

The case to be reported presents one of those rare conditions of childhood in which with the precocious appearance of hair on the face and pubes, and the equally precocious development of external genitals, there appears an abdominal tumor due to the growth of a hypernephroma of one adrenal body.

In an exhaustive article on this subject, with the report of one case, Jump, Beates and Babcock1 have collected from the literature records of seventeen cases, their own case making the eighteenth. In all the cases the conditions present were verified by a more or less complete necropsy. Other cases they find reported, but without necropsy, so that the diagnosis is in doubt. In one case necropsy showed both adrenals apparently normal, but the necropsy was brief, and the examination evidently superficial. Of the eighteen cases reported, fourteen were girls and four boys. In all there was an overgrowth

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