My first duty is the pleasant one of thanking you for your kindness in asking me to read this paper. I very much appreciate the honor you have shown me.
I have chosen "The Etiology and Pathology of Bone and Joint Tuberculosis" as the subject of my paper, because in Edinburgh we have lately been doing some work in this connection which may interest you.
It will aid later in understanding if I explain now that my remarks may be summarized under two headings: etiology and pathology.
The essential etiologic factor is, of course, the lodgment of the tubercle bacillus; but this primary factor is intimately related with two secondary considerations which are of great importance; and these two considerations are: (1) the type of bacillus which causes the disease, and (2) the route by which the organism reaches the site of its development.1. The Type of Bacillus
JOHN FRASER. THE ETIOLOGY AND PATHOLOGY OF BONE AND JOINT TUBERCULOSIS. JAMA. 1915;LXIV(1):17–24. doi:10.1001/jama.1915.02570270019005