The clinical history of syphilis, admittedly one of the most protean of all diseases, is in the process of being rewritten, and when the chapters are relatively complete it will be found that we are indebted rather to the laboratory worker than either the internist or neurologist for our more complete knowledge. It was at one time supposed that syphilis of the nervous system was a late manifestation of the disease, and this statement is generally true from the clinical point of view. Precocious syphilis was the term employed by Gowers for those cases in which patients manifest organic nervous phenomena within a year from the appearance of the primary lesion. For many years it has been recognized as a possibility, and cases have been reported by Gowers, Fournier, Oppenheim, Nonne and others, including an instance furnished by Gregory and Karpas of a case of cerebral syphilis occurring six months
ROBERTSON WE, KLAUDER JV. VARIOUS TYPES OF LUES: A CLINICAL AND LABORATORY STUDY. THE ABELIN REACTION. DIRECT SUBDURAL INJECTIONS. JAMA. 1915;LXIV(3):199–203. doi:10.1001/jama.1915.02570290011003
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