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July 29, 1916


JAMA. 1916;LXVII(5):362-363. doi:10.1001/jama.1916.02590050040018

Although the pathogenesis of gastric ulcer has long been associated in the minds of clinicians with the peculiar qualities of the gastric juice, a direct interrelationship is far from being demonstrated, and other etiologic factors must now be taken into account. It is doubtless true that gastric ulcer may occur wherever gastric juice flows. Whatever the relation between this secretion and the lesion may be, healing is apparently prevented in some way by the action of the gastric juice. Sippy1 has shown, in his treatment of gastric ulcer, that the gastric acidity appears to play an important rôle in establishing chronic ulcer. The neutralization of the gastric juice by the continued administration of alkalies, accordingly, appears to facilitate the cure of a large number of chronic gastric and duodenal ulcers.

To the varied conditions long regarded as possible factors aiding in ulcer formation, an added agency has demanded serious