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August 5, 1916


JAMA. 1916;LXVII(6):440-441. doi:10.1001/jama.1916.02590060040015

The helpful service which clinical calorimetry is performing in the development of scientific medicine is not confined to one or two diseases to which reference was recently made.1 Pernicious anemia, likewise still a puzzling malady, has claimed a share of attention from the investigators of the Russell Sage Institute of Pathology, in affiliation with the Second Medical Division of Bellevue Hospital, New York.2 This newer work differs from many of the earlier investigations in that the observations on the metabolism of the disease were made on patients instead of animals. Most anemias in the latter have been induced artificially by hemorrhage. When we come to the application of experimental methods to clinical anemia, the problem at once becomes decidedly more complicated. In addition to the simple anemias, there is the unique type of pernicious anemia. Chlorosis and leukemia may be included in the category because of their low