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It has been noted by different authors that in edemas of various types, as in those associated with heart disease, certain types of nephritis, etc., there is evidence of chlorid retention in the body. From this it has been quite generally concluded that in these conditions the kidneys are unable to eliminate chlorid (or, as ordinarily stated, are unable to eliminate sodium chlorid) and that its retention in the body is responsible for the edema. On such reasoning has been based the widely approved therapy of sodium chlorid restriction, and since a lessening of edema has at times been observed in patients following such restriction, the argument as a whole has been regarded as entirely sound.
Against it have stood, on the one hand, the failure of good observers to see any clinical improvement following careful efforts at applying the principles of sodium chlorid restriction, and on the other, the
FISCHER MH. RELATION BETWEEN CHLORID RETENTION, EDEMA AND "ACIDOSIS". JAMA. 1915;LXIV(4):325–326. doi:10.1001/jama.1915.02570300039012
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