There are a number of pathologic conditions in which large doses of sodium bicarbonate or other alkalies are indicated. The report of the two cases below, particularly Case 1, may serve to draw attention to an occasional consequence of such large administration of alkalies, which may lead to wrong conclusions if the possibility of its occurrence is not kept in mind. The condition referred to is the occasional appearance of generalized or localized edema in the course of administration of sodium bicarbonate.
—Woman, aged 51, was seen first, July 30, 1913. The patient had had diabetes mellitus for several years to her knowledge, and doubtless for some time before its discovery. The condition which I was called to see was a large carbuncle on the back between the shoulders. The urine at this time contained 5 per cent, of sugar. Diacetic acid and acetone were present. The carbuncle
LEVISON LA. THE OCCURRENCE OF EDEMA FROM LARGE DOSES OF SODIUM BICARBONATE. JAMA. 1915;LXIV(4):326–328. doi:10.1001/jama.1915.02570300040013
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