Most investigations intended to solve the mystery of the renal secretion and disclose the mechanism whereby the urine is produced in the kidneys have depended on the study of animals. The human subject has been referred to far less frequently to elucidate the function of the kidneys, presumably owing to the complexity and intimate association of the different portions of these organs and the consequent difficulty in connecting an experimental finding with a definite anatomic structure. In recent years distinct progress has been made in differentiating the involvement of the different portions of the kidney brought about by the inroad of disease. Types of nephritis which are purely glomerular and such as are interstitial in character have become more easily recognized and distinguished. Fundamental differences in the location of the inflammatory disturbance are now known to be associated not only with distinct histologic appearances in the kidney, but also with
CLINICAL DATA OF HUMAN RENAL DISEASE IN ELUCIDATION OF KIDNEY FUNCTION. JAMA. 1915;LXIV(4):346–347. doi:10.1001/jama.1915.02570300060025
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