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August 12, 1916

Observations on the Coagulation Test for Syphilis as Devised by Hirschfeld and Klinger

JAMA. 1916;LXVII(7):534-535. doi:10.1001/jama.1916.02590070058024

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To the Editor:  —Cole and Chiu (Arch. Int. Med., November, 1915, p. 880) made a report on some 600 serums and spinal fluids successfully examined in this laboratory by the coagulation test. These tests were all made in the late spring of 1915. At irregular intervals during the summer of 1915 and up to autumn of that year the coagulation test was successfully used in conjunction with the Wassermann reaction. Then it was noted that twice the amount of calcium chlorid was required for preparation of serozyme that had been used previously. The reaction then began to be very questionable in its results and remained so until late this spring. Since then, it has once more become quite trustworthy, and late in June sixty serums were examined consecutively and with uniform success.We were at first at a loss to explain this discrepancy, as well as the marked failure of

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