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Article
February 6, 1915

THE VIRULENCE OF THE ORGANISM GROWN FROM POLIOMYELITIC TISSUES

JAMA. 1915;LXIV(6):517. doi:10.1001/jama.1915.02570320041022
Abstract

Work during the past one or two years in this country and abroad has indicated possible methods for the control of poliomyelitis based on the discovery of mild or abortive cases of the disease. Of still greater importance, perhaps, is the demonstration of the presence of the virus of the disease in healthy persons who have been in contact with cases of poliomyelitis. Previous reference has been made5 to the great epidemiologic importance of "carriers" of the infection of poliomyelitis who may harbor the infective agent in their nasal mucosa, and yet have shown no symptoms of the disease. The successful cultivation of the causative organism, with the methods of cultivation devised by Noguchi, prompted the hope by students of the disease that we were on the eve of the announcement of the production or methods of active or passive immunization.

It has been established that the only sure

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