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Article
February 13, 1915

ALBUMIN IN THE SPUTUM AS A DIAGNOSTIC AID

JAMA. 1915;LXIV(7):574-576. doi:10.1001/jama.1915.02570330022007
Abstract

The suppression and cure of tuberculosis depend largely on an early diagnosis of the malady. Any laboratory method, therefore, which would be of value in our diagnosis, since both history and physical findings are often inadequate, would be very desirable.

Among the various methods for the diagnosis of tuberculosis which have been exploited from time to time is one, the albumin-sputum method, which has attracted attention off and on for nearly sixty years, but which never yielded sufficient satisfactory results to warrant its general adoption by clinicians.

REVIEW OF LITERATURE  In 1855 Biermer,1 investigating this subject, always found albumin positive in acute bronchitis, in pneumonia and in edema of the lungs, but negative in chronic bronchitis and in tuberculosis, the latter showing much mucin.Renk1 found albumin negative in chronic bronchitis but always positive in acute bronchitis, pneumonia and tuberculosis, the latter showing from 0.11 to 0.49 per

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