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November 16, 1889


JAMA. 1889;XIII(20):706. doi:10.1001/jama.1889.02401160020003

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A Comparison of Antipyretics.  —From a comparison of cases, in which he has carefully tabulated the effects produced, Dr. A. Crombie, of Calcutta, has reached the following conclusions:

  1. As regards efficacy, antipyrin comes first, and there is little to choose between antifebrin and phenacetin.

  2. Regarding safety, the advantage lies with phenacetin.

  3. As regards rapidity of action, antipyrin, probably on account of its solubility, comes first, antifebrin second, phenacetin third. The fall of temperature after the use of phenacetin is more gradual, and the minimum is not reached for three, four, or even five hours after the administration of the drug.

  4. As regards duration of effect, the advantage lies with phenacetin.

  5. As regards certainty of action, the order is the same as that of rapidity, i. e., antipyrin, antifebrin, phenacetin.

  6. As regards inconveniencies in a hot climate, like that of India, phenacetin is followed by just as profuse sweating as that

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