Transfusion of blood in cases of pernicious anemia is perhaps the first remedy that suggests itself for the treatment of the malady. It probably was tried long before it is recorded in the literature. Since the newer ways of transfusion with syringes and the citrate method have so simplified the operation, it has been tried innumerable times, but with only indifferent success. The best it has accomplished has been to initiate a remission in the course of the disease. There are many reasons why these transfusions have not been of more value. Chief among these is the lack of systematic treatment. Usually about as much good is accomplished by a single transfusion as is accomplished by a single inunction of mercury in the treatment of syphilis. Discredit has also been incurred by using blood which has not stood the proper tests and which is not only unsuitable but is often
McCLURE RD. PERNICIOUS ANEMIA TREATED BY SPLENECTOMY AND SYSTEMATIC, OFTENREPEATED TRANSFUSION OF BLOOD: TRANSFUSION IN BENZOL POISONING. JAMA. 1916;LXVII(11):793–798. doi:10.1001/jama.1916.02590110015005
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