Recently Brem1 has published a very comprehensive review of his results with his own practical application of Moss'2 principles. It would seem futile to try to add any information to that presented. Our own experience with Brem's microscopic method has proved its worth conclusively as a timesaving procedure in determining the suitability of donors for transfusion. However, in explaining the Moss agglutination groups to clinicians, we have found that some confusion arises regarding the relation of the four groups unless a careful study has been made of Moss' tables, but that the principles are readily grasped by referring to the accompanying diagram.
The diagram explains itself. Lansteiner's3 idea regarding the number of agglutinins is all that is necessary to explain the reaction, if we consider that the serum of Group II contains Agglutinin A and that of Group III contains agglutinin B, while Group IV contains both Agglutinin
Sanford AH. ISO-AGGLUTINATION GROUPS: A DIAGRAM SHOWING THEIR INTERRELATION. JAMA. 1916;LXVII(11):808–809. doi:10.1001/jama.1916.25910110001010
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