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Article
February 20, 1915

THE RELATION OF PITUITARY DISTURBANCES TO PARANOIDAL TRENDS

JAMA. 1915;LXIV(8):658. doi:10.1001/jama.1915.02570340030009

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Abstract

The more recent writings and monographs on the endocrine glands have afforded the medical profession a most fascinating field for study and experimentation. As the result, the somatic manifestations of secretory and other disturbances of these glands are fairly familiar and will not be dwelt on here.

In addition, however, to the pathognomonic somatic symptoms, disturbed functioning of the ductless glands gives rise to marked psychic phenomena of varying character and intensity, from idiocy and mental lethargy to the most agitated and apprehensive states. Thus far, I believe, these phenomena have failed to receive the attention which should be accorded them, and a great field is here opened to our American psychiatrists.

While the psychotic symptoms vary with the various glands affected, and in the same glandular disturbances in various individuals, yet in all cases I have seen of pituitary disturbance (not a large number, it is true), the mental

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