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Article
March 6, 1915

CLINICAL EXPERIENCE WITH LIQUID PARAFFIN (LIQUID PETROLATUM): A COMPARATIVE INVESTIGATION MADE UNDER THE AUSPICES OF THE COUNCIL ON PHARMACY AND CHEMISTRY

JAMA. 1915;LXIV(10):808-809. doi:10.1001/jama.1915.02570360024008

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Abstract

During the past three or four years, "mineral oil" has come into extensive use in the treatment of constipation. Preparations of the Russian and the American oil, both heavy and light, have appeared on the market, but there have been no satisfactory data on which to base a selection of oil for use. Therefore, in order to obtain reliable clinical information concerning the relative efficiency of the different oils, the Therapeutic Research Committee of the Council on Pharmacy and Chemistry of the American Medical Association submitted samples of the oils to various clinicians for testing. The following is a synopsis of the investigation, which I have prepared at the request of the committee.

The collaborators were advised that specimens of the best obtainable light Russian liquid petrolatum, heavy Russian liquid petrolatum and an American brand of liquid petrolatum would be sent out, but that, to avoid bias, these specimens would

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