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September 30, 1916


JAMA. 1916;LXVII(14):1022. doi:10.1001/jama.1916.02590140038013

In their pioneer investigation on the phenomena of anaphylaxis Rosenau and Anderson pointed out that the reaction is "quantitatively" specific, injections of horse serum sensitizing to horse serum only. Later they1 demonstrated further that an animal could be rendered sensitive at one and the same time to blood serum, egg white, and milk, acting specifically to each on second injection. In the earlier work in this field it seemed likely that the specificity, as a rule, is one of species. The protein of any animal was regarded as specific for the proteins of its particular species generally, there being definitely similar characteristics in the body proteins of animals of like species which, though chemically indefinable, are nevertheless delicately determinable by biologic reactions.

The question was accordingly early raised as to whether the specificity of the anaphylactic action depends primarily on the chemical structure of the protein used or on