Although Adami1 and certain other pathologists object to a sharp differentiation of tumors arising from the superficial epithelium into prickle-cell and basal-cell, it seems to me that the researches of Krompecher2 and Bloodgood3 have definitely established the fact that it is possible to draw such a line, both clinically and pathologically. In spite of the numerous publications of Bloodgood and his followers, there still exists considerable confusion as to the absolutely different form of treatment that is demanded by each type, a difference necessitated by the whole course of the cancerous process. In view of certain newer forms of treatment that are springing up, and that threaten to pay no attention to either the pathology or the clinical course of these tumors, it seems wise to restate the whole question again. The therapeutic measures to which I have reference are the Roentgen ray, radium and the various
HAZEN HH. PRICKLE-CELL AND BASAL-CELL SKIN CANCERS. JAMA. 1915;LXIV(12):958–961. doi:10.1001/jama.1915.02570380006002
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