No longer can there be any question that the menstrual cycle in woman, like the estrous cycle in animals, is dependent in some way on the presence of the ovaries. Ovariotomy performed subsequently to puberty in women produces less marked results than when carried out in early life. The most notable effect, however, always is the cessation of menstruation; and this is sometimes accompanied by an atrophy of the breasts and a tendency toward obesity. At one time the dependence of the phenomena of heat and menstruation on the presence of the ovaries was denied, because of alleged cases of the persistence of these functions after surgical ovariotomy. It seems probable, from investigation of specific cases, that the exceptional findings are in reality to be explained on the supposition that the extirpation of ovarian substance was not complete, and that the tissue which remained underwent hypertrophy subsequent to the operation.
THE OVARIAN FACTOR IN THE MENSTRUAL CYCLE. JAMA. 1915;LXIV(15):1246–1247. doi:10.1001/jama.1915.02570410044024
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