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April 10, 1915

Relationship of Veronal, Sulphonal and Trional

Author Affiliations


JAMA. 1915;LXIV(15):1265. doi:10.1001/jama.1915.02570410063038

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To the Editor:  —In the series of articles on "Practical Pharmacology," it is stated that "veronal is closely related chemically and therapeutically to sulphonal and trional," and that "its actions do not differ essentially from those of sulphonal and trional qualitatively" (The Journal, March 20, 1915, p. 994). As these statements, which are so commonly made, seem to me to be demonstrably incorrect, I feel that they ought not to be allowed to pass unchallenged. Of course all of these drugs belong to the series of aliphatic compounds and are therefore in a sense chemically related, but the chemical relation between veronal and sulphonal does not seem any closer than that between veronal and chloral, for instance. The characteristic radical of sulphonal is the ethyl-sulphone group (C2H5SO2) which is not found in veronal, while the carbamid group in veronal is not found in sulphonal. Chemically

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