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November 25, 1916


JAMA. 1916;LXVII(22):1599-1600. doi:10.1001/jama.1916.02590220041014

While carrying on the hookworm eradication work in Texas,1 I observed about 300 cases of hookworm disease treated with oil of chenopodium. Among these one case of poisoning occurred.

Oil of chenopodium, a volatile oil distilled from the Jerusalem oak or American wormseed, which is a common weed in many parts of the South, is being used with increasing frequency in the treatment of uncinariasis. It has been found preferable to thymol because it usually does not make the patients so sick and does not require that they fast for twenty-four hours or more; hence they are more willing to take treatments. It has been found very difficult to persuade patients to take a second or third course of treatment with thymol after they have been through the ordeal once, but the chenopodium ordinarily causes no discomfort whatever. Far fewer cases of toxic effects are on record from chenopodium