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November 25, 1916


JAMA. 1916;LXVII(22):1602-1603. doi:10.1001/jama.1916.02590220044017

That diabetes may represent something more farreaching 'than a failure to utilize carbohydrates alone in the organism has long been indicated by the evidences of disordered fat metabolism in this disease. Among these is lipemia, manifested as a cloudy or milky appearance of the serum of the blood due to the presence of fatty substances. Patients have been reported in whom the blood from the veins looked like chocolate and cream1 and in whom the vessels at necropsy appeared as whitish cords. Sometimes the fat has been reported as normal in quantity while the lipoids, cholesterol or lecithin, were much increased. It has been impossible to give any trustworthy conclusion as to what the lipemia essentially depends on, because there were too few actual analytic facts on which to base an accurate inference. The nutritive condition of the patients was rarely taken into account in formulating hypotheses as to