In working with the Abderhalden reaction in pregnancy or cancer we are dealing with a reaction which lends itself admirably to diagnostic work. With this reaction, as with all other laboratory tests, we are dealing with something which does not and cannot give absolutely accurate results (clinically). But experience has shown that the results obtained are accurate in a sufficiently large percentage of the cases to give it a place in the diagnostic armamentarium of the clinician.
It is not my intention in this short paper to give a description of the technic of the thimble method, nor to go into details of the theory on which this test is based. The thimble method, which is the method advocated by Abderhalden, and which is being used all over the world, contains a number of errors which appear at the most unexpected times and which invalidate the test to such a
LOWY O. THE APPLICATION OF THE VAN SLYKE AMINONITROGEN DETERMINATION TO THE DIAGNOSIS OF CANCER. JAMA. 1915;LXIV(19):1559–1560. doi:10.1001/jama.1915.02570450021006
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