If we view man and the lower animals as adaptive mechanisms, governed by the universal laws of physics and chemistry, then we must believe that every phase of human or animal behavior is occasioned by and in turn occasions physical and chemical changes in the body. Therefore an understanding of the vast alterations in the behavior of the anesthetized organism— changes which may range from the slightest depression of mental power through progressively deeper stages of unconsciousness to death, necessitates a search for the physical and chemical changes caused by the anesthetic. Accordingly, in this study we shall consider (a) the gross behavior of the anesthetized individual in a consideration of the relation of anesthesia to normal sleep; (b) the influence of ether and of nitrous oxid on the histologic structure of certain organs; (c) the relation of ether and of nitrous oxid to the hydrogen-ion concentration of the blood
CRILE GW. AN EXPERIMENTAL RESEARCH INTO THE NATURE OF NITROUS OXID AND OF ETHER ANESTHESIA: WITH SPECIAL REFERENCE TO CERTAIN EFFECTS ON THE ORGANS OF THE BODY, AND CERTAIN RELATIONS TO NORMAL SLEEP, HYDROGEN-ION CONCENTRATION AND INFECTIONS. JAMA. 1916;LXVII(25):1830–1831. doi:10.1001/jama.1916.02590250032010
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: