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December 16, 1916


Author Affiliations


From the Medical Clinic of City Hospital and the Pharmacological Laboratory, Western Reserve University.

JAMA. 1916;LXVII(25):1838-1842. doi:10.1001/jama.1916.02590250040015

There is no uniform agreement as to the appearance of albumin in urine, following the administration of salicylate in rheumatic and normal individuals. Its presence is claimed by some,1 and doubted or denied by others.2 Because of the confusion in the mode of application of tests for albumin, the origin of the albuminuria, that is, whether febrile or renal, has also remained unsettled. The object of the present contribution is to settle definitely whether or not salicylates can cause albuminuria, and if it is of febrile origin.

The excretion of albumin was studied qualitatively (heat and ferrocyanid tests), and quantitatively (gravimetric method of Folin and Denis3), together with phenolsulphonephthalein excretion in some and the nonprotein nitrogen of the blood in the majority, of sixteen patients. Nine of these suffered with rheumatic fever, and seven were nonrheumatic and practically normal. Sodium salicylate was administered in doses of 2