In spite of the attempts of several workers to disprove the claims made for sodium cacodylate as a powerful remedy in the treatment of syphilis, the drug is still extensively used by the general practitioner and by many specialists in the treatment of this disease. Yet Nichols,1 notably, by his work on rabbits, has proved that it is worthless as a spirocheticide.
To clear up the question as to its value, we undertook the study of its action2 in a series of selected syphilitics in our wards at the Cleveland City Hospital.
At first we started with a dose of 0.25 gm. intravenously, followed by a dose of 0.45 or 0.5 gm. every five days up to five or six injections. After one or two trials, however, we were convinced that we would have to use it either in larger doses or oftener if we were to obtain
COLE HN. A STUDY OF SODIUM CACODYLATE IN THE TREATMENT OF SYPHILIS. JAMA. 1916;LXVII(27):2012–2013. doi:10.1001/jama.1916.02590270032012
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