A combined pathologic, experimental and clinical study of Hodgkin's disease extending over a period of six years is the basis of this communication. The most efficacious methods of treatment will be presented with sufficient data to justify the various therapeutic procedures held to be indicated. Fischer1 was unable in 1901 to find a record of a single case in which cure was permanent. None has since then been reported in the literature up to the present year. We have been so fortunate as to have seen two recoveries (that is, five years without evidence of the disease) and at present have a small number of patients under observation who are in a very encouraging condition three to six years after beginning treatment. We believe the disease more common than supposed, more protean in its clinical manifestations than is generally accepted, and not of necessity universally fatal.This is
YATES JL, BUNTING CH. THE RATIONAL TREATMENT OF HODGKIN'S DISEASE. JAMA. 1915;LXIV(24):1953–1961. doi:10.1001/jama.1915.02570500001001
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