As the result of a series of animal experiments conducted at the Research Laboratory of the Department of Health by Dr. William H. Park and myself1 in order to determine the curative value of the intraspinal administration of tetanus antitoxin, and by which the superiority of this method was conclusively shown, every effort has been made during the past year to get into immediate touch with physicians and hospitals in and about the city of New York having cases of tetanus under their care, and induce them to give antitoxin as soon as possible by the following method:
From 3,000 to 5,000 units into the lumbar region of the spinal canal, preferably under an anesthetic, the volume of fluid injected being brought up to 10 or 15 c.c. by the addition of sterile normal saline, the exact amount being regulated according to the age of the patient and the amount
NICOLL M. INTRASPINAL ADMINISTRATION OF ANTITOXIN IN TETANUS: NOTES ON A SERIES OF CASES. JAMA. 1915;LXIV(24):1982–1984. doi:10.1001/jama.1915.02570500030012
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