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Article
June 12, 1915

PRACTICAL PHARMACOLOGY

JAMA. 1915;LXIV(24):1986-1989. doi:10.1001/jama.1915.25710500001016
Abstract

XXIII 

EVACUANTS—(Continued) 

3. EVACUANTS ACTING ON THE SMALL AND LARGE INTESTINES 

The Mercurials  The insoluble purgative mercurials, including calomel (mild mercurous chlorid), mass of mercury, (blue mass), and mercury with chalk (gray powder), have little action on the stomach unless their passage through it is delayed; their action on the intestine is mildly irritant, increasing peristalsis directly, and possibly increasing the secretion of the intestinal glands, thereby promoting peristalsis indirectly and causing soft stools with little or no pain, or with larger doses causing watery stools with some colic.Only a small part of the dose of a mercurial is absorbed when evacuation is induced promptly, but when there is interference with the movement of the intestinal contents the mercurials are absorbed. If there is great interference with the passage of the intestinal contents after a large dose of calomel, or other mercurial salt, diuresis is induced. This interference

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