Somebody has said that the serobiologic reactions have created a new science. It may also be said they have given us a new symptomatology. If we regard them as symptoms and not as reactions, they become much easier of understanding and interpretation. The lack of understanding concerning them has been due chiefly to two things: First, we do not know the source of the so-called antibodies which are necessary for a positive Wassermann, or the origin of the lymphocytosis or increase of globulin content which occurs not only in the spinal fluid but in the blood as well. Naturally, then, all our knowledge thus far in regard to these reactions has been obtained by the inductive method, that is, drawing conclusions from individual observations and striking an average or a percentage to be used in the formulation of genera rules about them from the sum total of observation.
BALL CR. A CONSIDERATION OF THE SEROBIOLOGIC REACTIONS AFTER FIVE YEARS OF OBSERVATION. JAMA. 1917;LXVIII(4):262–266. doi:10.1001/jama.1917.04270010262008
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