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June 26, 1915


JAMA. 1915;LXIV(26):2132-2137. doi:10.1001/jama.1915.25710520004008


ANTIEMETICS—GASTRIC SEDATIVES  This heterogeneous group, if it can be called a group, of drugs will be discussed briefly. The physiology of emesis which has been discussed in the preceding pages suggests the nature of those agents which may be used to lessen nausea and vomiting, for it is obvious that if emesis results from irritation of the gastric mucous membrane and from stimulation of the vomiting center in the medulla, emollients, demulcents, and other protective agents will lessen the local gastric irritation, and if relief is urgently demanded depression of the central nervous system may be resorted to, though this is seldom necessary, except as a temporary measure, for example, when it becomes necessary to prevent vomiting while administering a drug by the stomach.Unfortunately, we have no drug which depresses the vomiting center without causing an undesired depression of other nervous centers.Occasionally vomiting results from reflexes arising