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February 3, 1917

Sodium Cacodylate in the Treatment of Syphilis

Author Affiliations

Lynn, Mass.

JAMA. 1917;LXVIII(5):390. doi:10.1001/jama.1917.04270020070025

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To the Editor:  —I was much interested in the study of this subject by Dr. H. N. Cole (The Journal, Dec. 30, 1916, p. 2012).In 1913 I treated a series of cases of syphilis with sodium cacodylate; but, not getting the desired results, I discontinued its use. In 1915, I became interested again because of the writings of Dr. J. B. Murphy, and applied it in three cases in which the patients had initial lesions:

Case 1.  —J. M., man, aged 21, single, shoeworker, came to me with an initial lesion of the penis to the right of the frenum. I began intramuscular injections of sodium cacodylate, 5 grains, in ampuls made by Parke, Davis & Co., every day for ten days. Then I halted for ten days and repeated ten more injections. The sore on the penis entirely disappeared about the ninth day. There was a slight faintly

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