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June 26, 1915


JAMA. 1915;LXIV(26):2140-2141. doi:10.1001/jama.1915.02570520034012

It is conceivable theoretically that the protein present in albuminous urine is derived from the kidney or from the blood through damage to the capillary wall, or is a specific protein distinct from that derived from either the renal tissue or the blood. According to Fischer's widely discussed views, the urinary protein is derived, in part at least, from the renal cells, from which it has been dissolved under the influence of acids.1 In connection with a current belief that the urinary protein found in nephritis represents serum protein rather than tissue protein, we referred some time ago2 to the experiments of Salus,3 who attempted to solve the question by the use of modern serologic or biologic immunity reactions. The technic in this field has become so refined that different proteins from the same animal may possibly be distinguished, and it therefore seemed likely that the controverted