Periodically, we are told that interstitial gingivitis, or pyorrhea alveolaris, is caused by some special organism which the writer has just discovered. Specific investigation and attempts to corroborate these vaunted discoveries have always proved them to be erroneous. We are just beginning to recover from the shock of how little we know about the Endameba buccalis. The fact that a prominent research worker in medicine proclaimed to the world that the endameba was responsible for every case of pyorrhea, and that this disease was present in 95 per cent. of our population, has been the direct cause of much confusion. Physicians lacking education in mouth physiology and pathology were especially imposed on by this dogmatic assertion.
Research work which I have conducted in the mouths of animals has corroborated the work of general observers to the effect that infection is impossible in an individual otherwise physically well. Considering, as we
RHEIN ML. THE IMPORTANCE OF A CORRECT DIFFERENTIAL DIAGNOSIS OF THE PREDISPOSING CAUSES: IN CASES OF INTERSTITIAL GINGIVITIS OR PYORRHEA ALVEOLARIS. JAMA. 1917;LXVIII(6):417–418. doi:10.1001/jama.1917.04270020097004
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