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February 17, 1917

THE HECHT-WEINBERG-GRADWOHL TEST IN THE DIAGNOSIS OF SYPHILISITS SUPERIORITY OVER THE WASSERMANN TEST IN UNTREATED AND TREATED SYPHILITICS

JAMA. 1917;LXVIII(7):514-521. doi:10.1001/jama.1917.04270020178006
Abstract

It has taken about one decade to introduce the Wassermann test into the field of diagnosis. It is now recognized as one of the most valuable laboratory aids that has yet been brought into routine use. It is so nearrly specific in differentiating between syphilitic and nonsyphilitic conditions that for all practical purposes we may conclude that a positive Wassermann means syphilis.

This reaction is usually performed by competent workers along the lines orriginally laid down by Wassermann and the so-called Berlin school of serology. As a pupil and follower of that school I have insisted on the carrying out of a technic similar in all details to that originally advocated by Wassermann, with the exception of replacing the watery extracts of antigenic substance by one or more of the much superior alcoholic preparations. Using, therefore, the so-called "classical Wassermann" with the proper alcoholic antigen, cholesterinized or not as the

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