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The essential difference between the normal and the diabetic organism is the inability of the latter to utilize as much glucose as the former. This much may be said with certainty even though the structural defect of which this functional disability is the expression remains obscure. The evidence for and against it was discussed by Allen in 1913. He added new experimental evidence of his own in its favor, and since that time further data have been accumulated by others till there is now no reasonable room for doubt.
Accuracy in early diagnosis usually follows the ability to demonstrate one or other of the essential links in the chain of the causation of disease. The early diagnosis of typhoid and of syphilis is possible because the typhoid bacillus and the Spirochaeta pallida can be found. In these instances one of the ultimate factors in the etiology is demonstrable. But it
ADDIS T. THE EARLY DIAGNOSIS OF DIABETES: A SIMPLE METHOD INVOLVING STRAIN ON THE CAPACITY OF THE TISSUES TO UTILIZE GLUCOSE. JAMA. 1917;LXIX(2):109–111. doi:10.1001/jama.1917.02590290031009
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