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August 11, 1917


JAMA. 1917;LXIX(6):454-459. doi:10.1001/jama.1917.02590330038011

I do not believe we are in a position today scientifically to assert that there is such a thing as evolution of cancer of the breast. If cancer of the breast does occur as the result of a progressive series of processes, there have not as yet been made sufficient investigations definitely to demonstrate it as a fact.

My object in this paper is to review a certain amount of investigation which has been made by others in this direction and to attempt to correlate certain facts and thoughts, and if possible to initiate a standardized form of investigation, so that the future may give us data which we are at present lacking.

If we are to find that cancer of the breast develops by a process of evolution from the normal, I believe it will be found in a study of that complex disease, which, for want of a

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