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In health the urine of human adults rarely contains any noteworthy amount of creatin despite the constant presence of the closely related substance creatinin. In fasting and certain diseases, particularly such as are attended with more or less inanition, creatin may make its appearance in the secretion from the kidney. It is found in the urine of women after postpartum resolution of the uterus; and children commonly excrete creatin along with creatinin until the middle years of childhood.
Underhill1 has lately pointed out, in an experimental study on certain species, that a marked condition of acidosis, as measured by the hydrogen ion concentration of the urine, is always associated with the appearance of creatin in the rabbit. This may be brought about by feeding acid-forming foods. On the other hand, if a base-producing food, such as carrots, is fed to rabbits with creatinuria, this symptom rapidly disappears as the
CREATIN AND CREATININ IN BLOOD. JAMA. 1917;LXIX(8):648. doi:10.1001/jama.1917.02590350050016
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