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Opinions regarding the virtue of tuberculin still vary between extremes. Clinicians in general are dissatisfied with the results, while the pure experimentalists in the laboratory continue to observe direct effects. Koch maintains in force all his original propositions concerning its virtue, and his immediate associates and assistants attribute the failures to complications.
Tuberculin is known to be a product of the growth of the tubercle bacillus in a culture soil of veal broth containing 1 per cent. peptone and 5 per cent. glycerin. It is extracted with 40 to 50 per cent, glycerin so that it keeps almost indefinitely. I have some of the first, furnished nearly two years ago. It still shows the same effect as that obtained last month; that is, in dose of one milligram (1 per cent. solution), it excites its peculiar reaction in tuberculous patients.
We get some new light on the action of tuberculin
WHITTAKER JT. THE ACTION AND USE OF TUBERCULIN.Read in the Section of Practice of Medicine, at the Forty-fourth Annual Meeting of the American Medical Association. JAMA. 1893;XXI(3):78–81. doi:10.1001/jama.1893.02420550012001a
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