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Article
September 1, 1917

ORGANIC CHANGES IN THE CENTRAL NERVOUS SYSTEM PROBABLY DUE TO FOCAL INFECTIONS

JAMA. 1917;LXIX(9):689-691. doi:10.1001/jama.1917.02590360009003
Abstract

It is with a full knowledge of the vulnerable points which may be cited in reasoning from cause to effect that I present the history of these cases which compose the nucleus on which this paper is based. However, clinical evidence and resulting treatment in other cases not here reported encourage me to present this article, for I realize the fact that the chain of infection leading from the tonsils and teeth to the central nervous system in these cases is not complete, since two of the patients are still living.

Orr and Rows1 state that infections may ascend from deep foci of infection through the lymph channels which surround the spinal nerves and roots, and extend to the pia and there set up inflammatory reaction. They have observed such conditions in staphylococcus infection. They state that toxins can spread along the roots of these nerves without injuring the

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