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August 5, 1893


JAMA. 1893;XXI(6):179-182. doi:10.1001/jama.1893.02420580001001

Origin of Urea and Uric Acid.—Some of the recent editorials on this subject would lead us to infer that the function of the kidneys is not well understood, or that there is a wide difference of opinion regarding it. Merck's Bulletin, Dec. 18, 1892, says editorially: " Through the agency of the epithelial cells lining the uriniferous tubules the urea, uric acid and creatine are normally formed and discharged," etc. Again: " The function of the glomeruli is comparatively simple, being entirely under the control of the vasomotor system." Indeed, such statements as the foregoing are comparatively common, but ought not to go unchallenged. A knowledge of physiology should precede and serve as a basis for rational therapeutics, and the more thorough and more nearly correct the former, the more scientific and satisfactory will be the latter. Instead of calling the kidneys secreting organs and the urine an excretion, it