The desirability of a clinical method for determining the alkalinity of blood—that is to say, the OH and H ionization—has long been recognized. The recent determinations of this ionization by Friedenthal,1 Höber,2 Fraenkel,3 Farkas4 and Tangl and his pupils5 have shown that the alkalinity is very slight and subject to very little variation. Accordingly a clinical method has seemed difficult to seek. The recent study of indicators by Salm,6 however, characterizing with the greatest accuracy a whole series of indicators, has suggested the possibility of devising a method at once certain, accurate and easy of application. The present paper is concerned with experiments to this end.
There are two general methods by which the reaction of a fluid may be quantitatively measured: 1. Titration to an end point. 2. Determination of the H and OH ionization. The former yields information concerning the amount
ADLER HM. A CLINICAL METHOD FOR DETERMINING THE ALKALINITY OF THE BLOOD.. JAMA. 1907;XLIX(6):461–462. doi:10.1001/jama.1907.25320060011001c
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