This condition has, in common with diabetes, only the polyuria, and, although cases have been observed in which, after a time, glycosuria developed, yet with most of the typical cases the name diabetes insipidus is a misleading misnomer. At one time the view was advanced that the polyuria is secondary to a chronic polydipsia, and cases have been reported in which this condition seems to have existed, but these cases are of an atypical, transient form, dependent on neuroses, and quite distinct from the typical persistent form of the disease. Strubell found that in the typical cases a rise in the concentration of the blood soon follows a brief period of thirst, showing that the excessive renal secretion is not dependent on an excessive amount of liquid in the blood, as is the case in polyuria resulting from polydipsia. This and other observations have led to the view now prevailing
THE PATHOGENESIS OF DIABETES INSIPIDUS.. JAMA. 1907;XLIX(6):499–500. doi:10.1001/jama.1907.02530060049004
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