This study was made during the late summer of 1916, as part of the investigation by the Research Laboratory of the New York City Health Department on the value of pertussis vaccine in whooping cough.
Because of the infantile paralysis epidemic, car strikes and the expiration, October 1, of the lease of the building used for clinical purposes, the number of patients used for this study is far less than we could wish. The deductions, however, are suggestive, and show the danger of drawing conclusions too hastily and without making a critical comparison with control cases.
Dr. Luttinger, in his report of May, 1915, pointed out the pitfalls in accepting the statements of patients in the clinic; but in spite of the difficulties he encountered, he gathered from his records that pertussis vaccine lessened the duration of the whoop by 37.5 per cent, as against treatment with drugs. Hoag1 is
VON SHOLLY AI, BLUM J, SMITH L. THE THERAPEUTIC VALUE OF PERTUSSIS VACCINE IN WHOOPING COUGH. JAMA. 1917;LXVIII(20):1451–1456. doi:10.1001/jama.1917.04270050153002
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