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October 7, 1893

ADDITIONAL EXPERIENCES IN THE HYPODERMIC USE OF ARSENIC.Read before the Section of Neurology and Medical Jurisprudence, at the Forty-fourth Annual Meeting of the American Medical Association.

JAMA. 1893;XXI(15):530-532. doi:10.1001/jama.1893.02420670020001d

In a former communication we called attention to the value of the hypodermic method of giving arsenic and reported some eight cases all told in which it was employed. Since that time a large additional experience with the method has but confirmed our previous good opinion. The list now includes twenty-eight cases of chorea, three of paralysis agitans and eight cases of neurasthenia.

The hypodermic use of Fowler's solution has been recommended by numerous writers. Hammond claimed that the dose which could be administered in this way was much greater than could be safely administered by the mouth. He says:

"I have frequently given as high as 35 drops of Fowler's solution as an initial dose. It is very certain that the stomach would not tolerate this quantity. Again, I have often carried the amount given by the mouth to the utmost bounds of prudence—till the eyes were puffed and