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September 29, 1917


JAMA. 1917;LXIX(13):1083. doi:10.1001/jama.1917.02590400043017

Only a few years ago the chronic polyuria that was formerly referred to under the uncharacteristic designation of diabetes insipidus was regarded as a comparatively rare malady. The advance of clinical medicine has, however, brought to light an unexpected number of cases, some of which have been subjected to careful study with the aid of the newest methods of science. Although the pathogenesis of the disease is still decidedly debatable and many observers are inclined to associate it in some way with the central nervous system, other competent investigators have championed the hypothesis that chronic polyuria is primarily the result of a disease of the kidney.1

One salient characteristic of the disease is the inordinately low specific gravity and the enormous volumes of the urine. It has been maintained by those who incline to the kidney factor as the determining agency in the disease that the kidneys of affected